منابع مشابه
SnapShot: Neuronal Regulation of Aging
Aging is characterized by loss of homeostasis across multiple tissues. The nervous system governs whole-body homeostasis by communicating external and internal signals to peripheral tissues. Here, we highlight neuronal mechanisms and downstream outputs that regulate aging and longevity. Targeting these neuronal pathways may be a novel strategy to promote healthy aging. To view this SnapShot, op...
متن کاملSnapShot: Transcription Regulation: Pausing
Productive elongation Modes of P-TEFb Recruitment: TFs (e.g., MYC, NF-κB) Mediator (Med26 subunit or Cdk8 module) Acetylated histones and Brd4 Other elongation factors as part of the superelongation complex CRE DNA-binding transcription factors (TFs) associate with cis-regulatory elements (CRE) to promote assembly of the PIC. TFs can stimulate PIC formation directly through interactions with th...
متن کاملSnapShot: Hox Gene Regulation
d12 d13 d10 d11 d11 d13 d11 d10 d9 d8 d4 d3 d1 d12 c13 c11 c10 c9 c6 c5 c4 c12 c8 b13 b9 b7 b6 b5 b4 b3 b2 b1 b8 a13 a11 a10 a9 a7 a6 a5 a4 a3 a2 a1 HoxA HoxB HoxC d13 d11 d10 d9 d8 d4 d3 d1 d12
متن کاملAging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability.
Aging is associated with neurodegenerative processes. 5-Lipoxygenase (5-LO), which is also expressed in neurons, is the key enzyme in the synthesis of leukotrienes, inflammatory eicosanoids that are capable of promoting neurodegeneration. We hypothesized that neuronal 5-LO expression can be up-regulated in aging and that this may increase the brain's vulnerability to neurodegeneration. We obser...
متن کاملBlueberries and neuronal aging.
As the population of people in the United States over the age of 65 years continues to increase, so too will the incidence of age-related pathologies, including decreases in cognitive and motor function. In cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that unless some way is found to reduce these age-related de...
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ژورنال
عنوان ژورنال: Cell
سال: 2016
ISSN: 0092-8674
DOI: 10.1016/j.cell.2016.07.022